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4-Aminophenoxyacetic acids as a novel class of reversible cathepsin K inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Mar 15; Vol. 16 (6), pp. 1502-5. Date of Electronic Publication: 2005 Dec 27. - Publication Year :
- 2006
-
Abstract
- We have designed and synthesized a novel series of 3-biphenylamino acid amides as cathepsin K inhibitors based on compound I. In these inhibitors, we have discovered 4-aminophenoxyacetic acids 43 and 47 with good IC(50) values, although lipophilic groups are favorable for the hydrophobic S1' pocket.
- Subjects :
- Cathepsin K
Cathepsins metabolism
Cysteine Proteinase Inhibitors pharmacology
Humans
Phenoxyacetates pharmacology
Recombinant Proteins antagonists & inhibitors
Recombinant Proteins metabolism
Structure-Activity Relationship
Cathepsins antagonists & inhibitors
Cysteine Proteinase Inhibitors chemical synthesis
Phenoxyacetates chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16380250
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.12.053