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Acute uncomplicated lower urinary tract infections in general practice: clinical and microbiological cure rates after three- versus five-day treatment with trimethoprim.
- Source :
-
The European journal of general practice [Eur J Gen Pract] 2005 Jun; Vol. 11 (2), pp. 55-8. - Publication Year :
- 2005
-
Abstract
- Objectives: Epidemiological studies indicate that acute uncomplicated urinary tract infections (UTI) in women can be successfully treated with short treatment regimens. However, the findings from the literature do not match experiences in daily practice.<br />Methods: A randomised, controlled trial evaluating the microbiological and clinical (self-reported) cure rates of a three-day vs. five-day treatment regimen with trimethoprim for UTI in women.<br />Results: No statistically significant difference in bacteriological cure rate was found between the three-day and five-day regimen. One day after the shorter regimen 44% of women considered themselves as 'not-recovered' due to persistence of the symptoms compared with 35% after the five-day treatment (p > 0.05). Three days after therapy these percentages were 30 and 25% respectively.<br />Conclusion: The relatively high percentage of persistent symptoms one day after the three-day regimen might be responsible for general practitioners believing that short regimens are not successful. It is therefore advisable that if urine samples are controlled to wait at least three days after finishing treatment.
- Subjects :
- Acute Disease
Adolescent
Adult
Aged
Enterobacteriaceae Infections drug therapy
Escherichia coli drug effects
Escherichia coli isolation & purification
Family Practice
Female
Humans
Middle Aged
Proteus mirabilis drug effects
Proteus mirabilis isolation & purification
Surveys and Questionnaires
Time Factors
Treatment Outcome
Urinary Tract Infections microbiology
Anti-Infective Agents, Urinary therapeutic use
Trimethoprim therapeutic use
Urinary Tract Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1381-4788
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The European journal of general practice
- Publication Type :
- Academic Journal
- Accession number :
- 16392777
- Full Text :
- https://doi.org/10.3109/13814780509178238