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Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2006 Mar; Vol. 91 (3), pp. 1081-6. Date of Electronic Publication: 2006 Jan 04. - Publication Year :
- 2006
-
Abstract
- Context: The recently discovered hormone resistin is linked to the development of insulin resistance, but direct evidence of resistin levels in humans with nonalcoholic fatty liver disease (NAFLD) is lacking.<br />Methods: We conducted this study to assess the relationship between serum resistin and NAFLD. We measured serum resistin and biochemical, hormonal, and histological correlates in 28 NAFLD patients, 33 controls, and 30 obese patients [body mass index (BMI), >30 kg/m2] without NAFLD.<br />Results: Resistin and adiponectin expression were measured in sc adipose tissue by quantitative RT-PCR. Resistin was higher in NAFLD patients compared with controls (5.87 +/- 0.49 vs. 4.30 +/- 0.20 ng/ml; P = 0.002) and obese patients (4.37 +/- 0.27 ng/ml; P = 0.002). Increased resistin mRNA was also found in the adipose tissue of NAFLD patients compared with controls and obese subjects.<br />Conclusions: Both NAFLD and obese patients had lower adiponectin levels, whereas leptin was increased only in the obese group. No correlation was found between resistin and high-sensitivity C-reactive protein, BMI, homeostasis model assessment, insulin, glucose, transaminases, and lipid values. A positive correlation was found between resistin and histological inflammatory score. These data report increased resistin in NAFLD patients that is related to the histological severity of the disease, but do not support a link between resistin and insulin resistance or BMI in these patients.
- Subjects :
- Adiponectin blood
Adiponectin genetics
Adipose Tissue physiology
Adipose Tissue physiopathology
Adult
Body Mass Index
Fatty Liver physiopathology
Female
Humans
Leptin blood
Lipids blood
Liver Function Tests
Male
Middle Aged
Obesity blood
Reference Values
Resistin genetics
Reverse Transcriptase Polymerase Chain Reaction
Severity of Illness Index
Fatty Liver blood
Insulin Resistance physiology
Resistin blood
Subjects
Details
- Language :
- English
- ISSN :
- 0021-972X
- Volume :
- 91
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 16394091
- Full Text :
- https://doi.org/10.1210/jc.2005-1056