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Human papillomavirus infection in Rio de Janeiro, Brazil: a retrospective study.
- Source :
-
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2005 Oct; Vol. 9 (5), pp. 398-404. Date of Electronic Publication: 2006 Jan 06. - Publication Year :
- 2005
-
Abstract
- There is considerable data to support a central role for human papillomavirus (HPV) in the etiology of cervical cancer. More than a 100 HPV types have been described, and 40 have been isolated from benign and malignant genital lesions. Consequently, there is strong motivation to evaluate HPV testing for cervical cancer screening. Few studies concerning the natural history of HPV infection have been conducted in the state of Rio de Janeiro. We determined the prevalence of HPV types in female genital lesions by using Hybrid Capture Assay (HCA) and we retrospectively analyzed the course of HPV infection. Our sample included 788 women attended at Laboratórios Sérgio Franco. The average age of the participants was 29.6 years. HPV prevalence and cytological diagnosis were determined. The overall prevalence of HPV DNA in the study group was 50.1% (395/788), ranging from 25% (NORMAL) to 100% in high-grade intraepithelial lesions (HSIL). High risk HPV was found in 12% inflammatory, 58.3% HPV, 63.2% LSIL and 100% HSIL. A retrospective analysis of 78 patients showed that 22 presented persistent lesions, 2 had progressive lesions, 4 had regressive lesions, 13 showed latent infections, 18 were transiently infected and 19 were submitted to curative treatment. No cases of cancer were registered in this population, which can afford private medical care and regular follow-up exams. We suggest that HCA be used in specific cases involving persistent and recurrent lesions.
- Subjects :
- Adolescent
Adult
Brazil epidemiology
Child
DNA, Viral isolation & purification
Disease Progression
Female
Follow-Up Studies
Humans
In Situ Hybridization
Middle Aged
Papillomaviridae genetics
Papillomaviridae pathogenicity
Papillomavirus Infections complications
Papillomavirus Infections pathology
Retrospective Studies
Risk Factors
Uterine Cervical Neoplasms pathology
Uterine Cervical Dysplasia pathology
Mass Screening
Papillomaviridae isolation & purification
Papillomavirus Infections epidemiology
Uterine Cervical Neoplasms virology
Vaginal Smears
Uterine Cervical Dysplasia virology
Subjects
Details
- Language :
- English
- ISSN :
- 1413-8670
- Volume :
- 9
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 16410891
- Full Text :
- https://doi.org/10.1590/s1413-86702005000500007