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Copper complexes of thiosemicarbazone-pyridylhydrazine (THYNIC) hybrid ligands: a new versatile potential bifunctional chelator for copper radiopharmaceuticals.
- Source :
-
Inorganic chemistry [Inorg Chem] 2006 Jan 23; Vol. 45 (2), pp. 496-8. - Publication Year :
- 2006
-
Abstract
- Two new thiosemicarbazone-pyridylhydrazine (THYNIC) hybrid ligands have been synthesized. Copper(II) and copper(I) complexes of the ligands have been prepared and characterized by X-ray crystallography. Cyclic voltammetry measurements show that the copper(II) complexes undergo quasi-reversible reductions at biologically accessible potentials. One of the ligands, bearing a pendant carboxylate arm, has been conjugated to N-alpha-(tert-butoxycarbonyl)-L-lysine.
- Subjects :
- Chelating Agents chemistry
Crystallography, X-Ray
Ligands
Models, Molecular
Molecular Structure
Organometallic Compounds chemistry
Radiopharmaceuticals
Chelating Agents chemical synthesis
Copper chemistry
Hydrazines chemistry
Organometallic Compounds chemical synthesis
Thiosemicarbazones chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0020-1669
- Volume :
- 45
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Inorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 16411680
- Full Text :
- https://doi.org/10.1021/ic0514492