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Conditioning method determines patterns of c-fos expression following novel taste-illness pairing.
- Source :
-
Behavioural brain research [Behav Brain Res] 2006 Apr 25; Vol. 169 (1), pp. 93-7. Date of Electronic Publication: 2006 Jan 19. - Publication Year :
- 2006
-
Abstract
- Conditioned taste aversions (CTAs) can be established by exposing rats to a novel taste CS through a bottle or through intra-oral (IO) infusion. Lesion studies suggest differences between the two methods in their engagement of brain circuits, as excitotoxic amygdala lesions have no effect on bottle-conditioned CTAs, but eliminate CTAs produced using IO infusion. Fos-like immunoreactivity (FLI) was used to compare patterns of brain activation after pairing CS taste and US drug using bottle and IO methods. Conditioning rats using the bottle method was associated with widespread elevations in FLI throughout the putative CTA circuit (basolateral and central nuclei of amygdala, insular cortex and nucleus of the solitary tract). In contrast, IO conditioning led to activation only in the central nucleus of amygdala. This supports the suggestion of differences in aversion processing as a function of conditioning method and may explain the greater reliance on amygdala of IO-conditioned CTAs due to engagement of a less distributed neural network.
- Subjects :
- Administration, Oral
Amygdala metabolism
Animals
Association Learning physiology
Avoidance Learning drug effects
Behavioral Research methods
Cerebral Cortex metabolism
Drinking Behavior drug effects
Drinking Behavior physiology
Lithium Chloride administration & dosage
Male
Rats
Rats, Long-Evans
Solitary Nucleus metabolism
Taste drug effects
Tissue Distribution
Avoidance Learning physiology
Conditioning, Psychological physiology
Neural Pathways metabolism
Proto-Oncogene Proteins c-fos metabolism
Taste physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0166-4328
- Volume :
- 169
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 16427145
- Full Text :
- https://doi.org/10.1016/j.bbr.2005.12.006