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[Two cases of pulmonary aspergillosis successfully treated with combinated micafungin and itraconazole therapy].
- Source :
-
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases [Kansenshogaku Zasshi] 2005 Dec; Vol. 79 (12), pp. 951-6. - Publication Year :
- 2005
-
Abstract
- We report 2 cases of pulmonary aspergillosis treated successfully by combining micafungin and traconazole. Case 1: A 51-year-old man with hemoptysis and dyspnea on effort treated for pulmonary tuberculosis and aspergillosis was found on chest CT on admission to have a fungus ball in the left upper lobe and increasing consolidation around the cavity of both lung fields. Bronchoscopy proved positive for aspergillus PCR in bronchial lavage. He was diagnosed with chronic necrotizing pulmonary aspergillosis, based on clinical and radiological findings and the positive reaction for aspergillus PCR. He was treated with micafungin alone at first, this proved ineffective, so itraconazole was added, resulting in improvement. Case 2: A 24-year-old woman with stabilized Hodgkin's disease (mixed). She had suffered from a cough and back pain, and chest CT showed increasing consolidation inside and around a giant bulla. She was diagnosed with chronic necrotizing pulmonary aspergillosis, based on isolation for Aspergillus sp. in sputum culture and a positive reaction for Aspergillus antigen in bronchial lavage and Aspergillus antibody in serum. She was treated with the combined micafungin and itraconazole, which rapidly improved symptoms and radiological findings. Pulmonary aspergillosis therapy is often difficult, because delivery of the drug to the infection site is limited and drug tolerance is poor. We found that combination micafungin and itraconazole therapy is tolerable and effective in these cases.
- Subjects :
- Adult
Aspergillosis diagnosis
Bronchoalveolar Lavage
Drug Administration Schedule
Drug Therapy, Combination
Echinocandins
Female
Humans
Lipopeptides
Lung Diseases, Fungal diagnosis
Male
Micafungin
Middle Aged
Tomography, X-Ray Computed
Antifungal Agents administration & dosage
Aspergillosis drug therapy
Itraconazole administration & dosage
Lipoproteins administration & dosage
Lung Diseases, Fungal drug therapy
Peptides, Cyclic administration & dosage
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0387-5911
- Volume :
- 79
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 16444977
- Full Text :
- https://doi.org/10.11150/kansenshogakuzasshi1970.79.951