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Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Apr 01; Vol. 16 (7), pp. 1929-33. Date of Electronic Publication: 2006 Jan 30. - Publication Year :
- 2006
-
Abstract
- A new series of erythromycin A derivatives, the 6-O-heteroarylcarbamoyl-11,12-lactoketolides, with activity against macrolide-resistant streptococci, are described. Structurally, these macrolide antibiotics are characterized by a heteroaryl side chain attached to the macrolactone core through a carbamate linkage at the C6 position, as well as 11,12-gamma-lactone and 3-keto functionalities. The synthesis and antibacterial activity of this new series of ketolides are discussed.
- Subjects :
- Anti-Bacterial Agents pharmacology
Haemophilus influenzae drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Streptococcus pneumoniae drug effects
Structure-Activity Relationship
Anti-Bacterial Agents chemical synthesis
Ketolides chemical synthesis
Ketolides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16446089
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.12.097