Back to Search
Start Over
Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Apr 01; Vol. 16 (7), pp. 1788-94. Date of Electronic Publication: 2006 Feb 03. - Publication Year :
- 2006
-
Abstract
- A novel series of P1 modified HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and protease inhibitor-resistant viruses. Optimization of the P1 moiety resulted in compounds with femtomolar enzyme activities and cellular antiviral activities in the low nanomolar range culminating in the identification of clinical candidate GW0385.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16458505
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.01.035