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Paraplegia due to spinal cord compression by extramedullary erythropoietic tissue in a thalassaemia intermedia patient with gynecomastia secondary to cirrhosis: successful treatment with hydroxyurea.
- Source :
-
Pediatric endocrinology reviews : PER [Pediatr Endocrinol Rev] 2004 Dec; Vol. 2 Suppl 2, pp. 316-8. - Publication Year :
- 2004
-
Abstract
- We report a 24 years old patient with thalassaemia intermedia and gynecomastia, complicated by paraplegia and urinary/fecal incontinence due to spinal cord compression by an extramedullary erythropoiesis (EE) mass, treated with long-term hydroxyurea (HU). Neurological improvement occurred during the first 6 weeks of HU therapy (1,000 mg/day) and magnetic resonance imaging showed a reduction in EE mass. HU dosage was reduced to 500 mg/day after 5 months, and treatment was discontinued after 25 months. Five months later there was a partial recurrence of neurological symptoms, which responded to radiotherapy. HU may have a role in the symptomatic treatment of spinal cord compression due to EE, particularly when radiotherapy is unavailable.
- Subjects :
- Adult
Antisickling Agents therapeutic use
Erythropoiesis drug effects
Humans
Hydroxyurea therapeutic use
Liver Cirrhosis complications
Male
Paraplegia drug therapy
Paraplegia pathology
Spinal Cord Compression drug therapy
Spinal Cord Compression pathology
Gynecomastia complications
Paraplegia complications
Spinal Cord Compression complications
beta-Thalassemia complications
Subjects
Details
- Language :
- English
- ISSN :
- 1565-4753
- Volume :
- 2 Suppl 2
- Database :
- MEDLINE
- Journal :
- Pediatric endocrinology reviews : PER
- Publication Type :
- Academic Journal
- Accession number :
- 16462720