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Substituted coumarins as potent 5-lipoxygenase inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 May 01; Vol. 16 (9), pp. 2528-31. Date of Electronic Publication: 2006 Feb 07. - Publication Year :
- 2006
-
Abstract
- Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure-activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16464579
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.01.085