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Rheumatoid factors react with Fab fragments of monoclonal antibodies to herpes simplex virus types 1 and 2 Fc gamma-binding proteins.
- Source :
-
Arthritis and rheumatism [Arthritis Rheum] 1991 Jul; Vol. 34 (7), pp. 846-55. - Publication Year :
- 1991
-
Abstract
- Human polyclonal IgM rheumatoid factors (RF) were tested in an enzyme-linked immunosorbent assay with monoclonal antibodies (MAb) (II-481 and B10/A8) to glycoprotein E (gE), the Fc gamma-binding protein of herpes simplex virus type 1 (HSV-1), as well as with MAb 88-S to gE of HSV-2. Most of the RF reacted with II-481 and 88-S. Positive reactions were recorded for RF reacting with whole MAb II-481 and 88-S, as well as with their Fab, but not their Fc, fragments. Human monoclonal IgM RF isolated from mixed cryoglobulins showed a similar profile, with reactivity for both whole MAb II-481 and 88-S and for their Fab fragments. Reactivity with MAb to gE was observed regardless of the Gm specificity of the polyclonal RF and the cross-reactive idiotypes (6B6, 17.109, or G6) of the monoclonal RF. No positive reactions were noted between protein A and Fab fragments of any of the anti-gE MAb. These findings indicate that many RF may bear the internal image of the Fc gamma-binding regions of 2 different herpesviruses: HSV-1 and HSV-2.
- Subjects :
- Antibody Specificity
Antigen-Antibody Reactions
Humans
Receptors, IgG
Antibodies, Monoclonal immunology
Antigens, Differentiation immunology
Immunoglobulin Fab Fragments immunology
Immunoglobulin Fc Fragments immunology
Receptors, Fc immunology
Rheumatoid Factor immunology
Simplexvirus immunology
Viral Envelope Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-3591
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Arthritis and rheumatism
- Publication Type :
- Academic Journal
- Accession number :
- 1647772
- Full Text :
- https://doi.org/10.1002/art.1780340710