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Recovery of drug-resistant influenza virus from immunocompromised patients: a case series.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2006 Mar 15; Vol. 193 (6), pp. 760-4. Date of Electronic Publication: 2006 Feb 13. - Publication Year :
- 2006
-
Abstract
- Influenza virus with resistance to antiviral drugs emerges with increased frequency in immunocompromised patients and can limit the benefit of M2 and neuraminidase (NA) inhibitors. We document 3 cases of influenza in severely immunocompromised patients from whom virus variants with molecular markers of resistance to anti-influenza drugs were recovered. Virus variants recovered from 2 patients had mutations in the M2, NA (with a previously recognized Glu119Val NA substitution), and hemagglutinin genes. We describe a novel Asp198Asn NA mutation in an influenza B virus and its decreased susceptibility to both oseltamivir and zanamivir.
- Subjects :
- Antiviral Agents pharmacology
Cell Line
Humans
Immunocompromised Host
Influenza A virus enzymology
Influenza A virus genetics
Influenza B virus genetics
Mutation
Neuraminidase antagonists & inhibitors
Drug Resistance, Viral genetics
Enzyme Inhibitors pharmacology
Influenza A virus drug effects
Influenza B virus drug effects
Neuraminidase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 193
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 16479508
- Full Text :
- https://doi.org/10.1086/500465