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Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups.
- Source :
-
Epidemiology and infection [Epidemiol Infect] 2006 Apr; Vol. 134 (2), pp. 211-21. - Publication Year :
- 2006
-
Abstract
- We systematically reviewed the current understanding of human population immunity against SARS-CoV in different groups, settings and geography. Our meta-analysis, which included all identified studies except those on wild animal handlers, yielded an overall seroprevalence of 0.10% [95% confidence interval (CI) 0.02-0.18]. Health-care workers and others who had close contact with SARS patients had a slightly higher degree of seroconversion (0.23%, 95% CI 0.02-0.45) compared to healthy blood donors, others from the general community or non-SARS patients recruited from the health-care setting (0.16%, 95% CI 0-0.37). When analysed by the two broad classes of testing procedures, it is clear that serial confirmatory test protocols resulted in a much lower estimate (0.050%, 95% CI 0-0.15) than single test protocols (0.20%, 95% CI 0.06-0.34). Potential epidemiological and laboratory pitfalls are also discussed as they may give rise to false or inconsistent results in measuring the seroprevalence of IgG antibodies to SARS-CoV.
- Subjects :
- Antibody Formation
Blood Donors
Geography
Health Personnel
Humans
Seroepidemiologic Studies
Immunoglobulin G analysis
Severe acute respiratory syndrome-related coronavirus immunology
Severe acute respiratory syndrome-related coronavirus pathogenicity
Severe Acute Respiratory Syndrome immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0950-2688
- Volume :
- 134
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Epidemiology and infection
- Publication Type :
- Academic Journal
- Accession number :
- 16490123
- Full Text :
- https://doi.org/10.1017/S0950268805004826