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Independent risk factors for anemia in cancer patients receiving chemotherapy: results from the European Cancer Anaemia Survey.
- Source :
-
Oncology [Oncology] 2006; Vol. 70 (1), pp. 34-48. Date of Electronic Publication: 2006 Feb 21. - Publication Year :
- 2006
-
Abstract
- Objectives: To develop a hitherto unavailable risk factor model for accurately predicting anemia development in cancer patients before chemotherapy (CT) administration.<br />Methods: 2,070 nonanemic patients from the European Cancer Anaemia Survey (ECAS) with hemoglobin (Hb) > or =12 g/dl at enrollment who received their first CT during ECAS and underwent at least two CT cycles were divided randomly into split half (SH) 1 and SH2 (n = 1,035 each). The model was developed on SH1 using logistic regression to simultaneously evaluate predictive factors, and was validated using SH2 and an additional similar subpopulation of 5,901 ECAS patients. Anemia risk values were assigned to the predictive factors and the sum of the predictive factors gave the total anemia risk score; lower-, higher-, and highest-risk cutoff points of the total anemia risk score were determined.<br />Results: Variables ultimately identified as significant predictive factors for anemia were: lower initial Hb (< or =12.9 g/dl in females, and < or =13.4 g/dl in males); having lung or gynecologic cancer versus gastrointestinal (GI)/colorectal cancer; cancer at any other site versus GI/colorectal cancer; treatment with platinum CT, and female gender.<br />Conclusion: Using this evidence-based risk model, nonanemic patients who are at the highest risk of developing anemia prior to receiving CT can be identified clinically, allowing appropriate anemia management to be planned.<br /> (Copyright 2006 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Anemia, Hypochromic etiology
Anemia, Hypochromic prevention & control
Area Under Curve
Europe
Evidence-Based Medicine
Female
Humans
Incidence
Logistic Models
Male
Middle Aged
Models, Statistical
Predictive Value of Tests
ROC Curve
Risk Factors
Surveys and Questionnaires
Anemia, Hypochromic epidemiology
Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 0030-2414
- Volume :
- 70
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 16493206
- Full Text :
- https://doi.org/10.1159/000091675