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Obstructive primary bladder neck disease: evaluation of the efficacy and safety of alpha1-blockers.
- Source :
-
Urologia internationalis [Urol Int] 2006; Vol. 76 (2), pp. 150-3. - Publication Year :
- 2006
-
Abstract
- Objective: The efficacy and safety of using alpha(1)-adrenergic blockers for treating primary bladder neck obstruction in young and middle-aged men was assessed as the first therapeutic step, before surgery, in a symptomatic non-neurogenic selected group of patients.<br />Materials and Methods: From January 1995 to December 2001, primary bladder neck obstruction was diagnosed in 41 men whose average age was 43 years. All of them were evaluated by a complete clinical history, American Urological Association (AUA) symptom score index, physical examination, uroflowmetry, transabdominal ultrasound prostatic volume determination, ultrasound post-void residual determination, videourodynamics including pressure-flow analysis and upper urinary tract screening with renal ultrasound or an excretory urogram. A full daily dose of alpha(1)-adrenergic blockers (alfuzosin or tamsulosin) was administered for at least 6 months. Successful treatment was defined as improved symptoms, voiding diary, maximum flow rate and pressure-flow parameters. Patients who did not gain improvement of symptoms with pharmacological treatment were offered surgery.<br />Results: Overall, pharmacological treatment was successful in 29/41 patients (70.7%) whereas bladder neck endoscopic incision was mandatory in 12/41 (29.3%).<br />Conclusions: alpha(1)-Blockers were effective and safe for treating young and middle-aged men with symptomatic bladder neck obstruction.
- Subjects :
- Adrenergic alpha-Antagonists adverse effects
Adult
Humans
Male
Middle Aged
Quinazolines adverse effects
Sulfonamides adverse effects
Tamsulosin
Time Factors
Adrenergic alpha-Antagonists therapeutic use
Quinazolines therapeutic use
Sulfonamides therapeutic use
Urinary Bladder Neck Obstruction drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0042-1138
- Volume :
- 76
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Urologia internationalis
- Publication Type :
- Academic Journal
- Accession number :
- 16493217
- Full Text :
- https://doi.org/10.1159/000090879