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Molecular characterization of isoniazid resistance in Mycobacterium tuberculosis: identification of a novel mutation in inhA.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2006 Mar; Vol. 50 (3), pp. 1075-8. - Publication Year :
- 2006
-
Abstract
- Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.
- Subjects :
- Alleles
Catalase genetics
Catalase metabolism
Codon
DNA, Bacterial analysis
DNA, Bacterial genetics
Drug Resistance, Bacterial genetics
Humans
Kinetics
Microbial Sensitivity Tests
Mycobacterium tuberculosis drug effects
Mycobacterium tuberculosis isolation & purification
Peroxidases genetics
Polymerase Chain Reaction
Sequence Analysis, DNA
Antitubercular Agents pharmacology
Bacterial Proteins genetics
Genes, Bacterial
Isoniazid pharmacology
Mycobacterium tuberculosis genetics
Point Mutation
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 50
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 16495272
- Full Text :
- https://doi.org/10.1128/AAC.50.3.1075-1078.2006