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Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes.
- Source :
-
Journal of virology [J Virol] 2006 Mar; Vol. 80 (6), pp. 2863-72. - Publication Year :
- 2006
-
Abstract
- Herpes simplex virus (HSV) infections of humans are characterized by intermittent, lytic replication in epithelia. Circulating HSV-specific CD4 T cells express lower levels of preformed cutaneous lymphocyte-associated antigen (CLA), a skin-homing receptor, than do circulating HSV-specific CD8 T cells but, paradoxically, move into infected skin earlier than CD8 cells. Memory CD4 T cells develop strong and selective expression of CLA and E-selectin ligand while responding to HSV antigen in vitro. We now show that interleukin-12, type I interferon, and transforming growth factor beta are each involved in CLA expression by memory HSV type 2 (HSV-2)-specific CD4 T cells in peripheral blood mononuclear cells (PBMC). A reduction of the number of monocytes and dendritic cells from PBMC reduces CLA expression by HSV-2-responsive CD4 lymphoblasts, while their reintroduction restores this phenotype, identifying these cells as possible sources of CLA-promoting cytokines. Plasmacytoid dendritic cells are particularly potent inducers of CLA on HSV-reactive CD4 T cells. These observations are consistent with cooperation between innate and acquired immunity to promote a pattern of homing receptor expression that is physiologically appropriate for trafficking to infected tissues.
- Subjects :
- Antigens, Differentiation, T-Lymphocyte
Antigens, Neoplasm
Antigens, Viral immunology
Humans
Immunity, Innate
Lymphocyte Activation
Skin metabolism
CD4-Positive T-Lymphocytes metabolism
Dendritic Cells immunology
Herpesvirus 2, Human immunology
Immunologic Memory
Membrane Glycoproteins metabolism
Receptors, Lymphocyte Homing metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-538X
- Volume :
- 80
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 16501095
- Full Text :
- https://doi.org/10.1128/JVI.80.6.2863-2872.2006