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Epitope specificity of serum antibodies directed against the extracellular domain of myelin oligodendrocyte glycoprotein: Influence of relapses and immunomodulatory treatments.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2006 May; Vol. 174 (1-2), pp. 147-56. Date of Electronic Publication: 2006 Mar 06. - Publication Year :
- 2006
-
Abstract
- Only few reports are available on the epitope specificity of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in multiple sclerosis (MS). In the present study we provide a precise characterization of the epitope specificity of serum antibodies directed against the extracellular domain of MOG, including IgG, IgM and IgA immunoglobulin isotypes in 28 relapsing remitting MS patients and report that linear epitopes amino-acid (aa) 37-48 and aa42-53 are immunodominant. Recently experienced relapses intensified the anti-MOG peptide antibody response. Immunomodulatory treatment with interferon-beta or glatiramer-acetate had no major impact on the anti-MOG peptide immunoreactivity after 1 year of therapy.
- Subjects :
- Adult
Amino Acid Sequence
Case-Control Studies
Female
Humans
Immunoassay methods
Male
Middle Aged
Multiple Sclerosis prevention & control
Myelin Proteins
Myelin-Oligodendrocyte Glycoprotein
ROC Curve
Secondary Prevention
Sensitivity and Specificity
Time Factors
Antibodies blood
Antibody Specificity physiology
Epitopes blood
Immunologic Factors therapeutic use
Multiple Sclerosis therapy
Myelin-Associated Glycoprotein immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 174
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 16516980
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2006.01.012