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Determinants of epidermal nerve fiber density in normal individuals.

Authors :
Umapathi T
Tan WL
Tan NC
Chan YH
Source :
Muscle & nerve [Muscle Nerve] 2006 Jun; Vol. 33 (6), pp. 742-6.
Publication Year :
2006

Abstract

We studied the relationship between epidermal innervation and age, gender, height, and weight. Intraepidermal nerve fiber density (IENFD) of skin biopsies obtained from the proximal thigh and ankle of 84 normal individuals was quantified. A linear regression model was performed using IENFD at the thigh, IENFD at the ankle, and the thigh IENFD/ankle IENFD ratio, with age, gender, and height-weight interaction as predictors. An independent, negative correlation was found between age and IENFD at the ankle. No correlation was found between age and IENFD at the thigh. With increasing age the thigh IENFD/ankle IENFD ratio, a measure of the length-dependent distal-to-proximal gradient of epidermal nerve density, increased significantly. Gender, height, and body weight did not independently influence IENFD at either site. In normal individuals, distal epidermal innervation decreases in a length-dependent manner with advancing age. This must be considered when interpreting IENFD in disease states.

Details

Language :
English
ISSN :
0148-639X
Volume :
33
Issue :
6
Database :
MEDLINE
Journal :
Muscle & nerve
Publication Type :
Academic Journal
Accession number :
16523506
Full Text :
https://doi.org/10.1002/mus.20528