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Hyperhomocysteinemia and functional cobalamin deficiency due to granulocytosis-induced alterations in the cobalamin-binding protein.
- Source :
-
Haematologica [Haematologica] 2006 Mar; Vol. 91 (3), pp. 394-6. - Publication Year :
- 2006
-
Abstract
- Serum cobalamin and homocysteine levels were studied in patients with chronic myelogenous leukemia (CML) and in stem cell donors treated with granulocyte-colony stimulating factor (G-CSF). Cytoreductive treatment in patients with CML resulted in a decrease of cobalamin and homocysteine levels. In stem cell donors cobalamin and homocysteine levels increased after G-CSF administration. The increase of homocysteine level was accompanied by a decrease in the serum levels of the cobalamin-binding protein transcobalamin. We hypothesize that the increased homocysteine levels in patients with CML and donors treated with G-CSF may be the result of a functional methylcobalamin deficiency due to decreased transcobalamin levels.
- Subjects :
- Granulocyte Colony-Stimulating Factor therapeutic use
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive blood
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Hyperhomocysteinemia blood
Transcobalamins metabolism
Vitamin B 12 analogs & derivatives
Vitamin B 12 blood
Vitamin B 12 Deficiency blood
Subjects
Details
- Language :
- English
- ISSN :
- 1592-8721
- Volume :
- 91
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 16531264