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Control of bisphosphonate release using hydroxyapatite granules.

Authors :
Seshima H
Yoshinari M
Takemoto S
Hattori M
Kawada E
Inoue T
Oda Y
Source :
Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2006 Aug; Vol. 78 (2), pp. 215-21.
Publication Year :
2006

Abstract

The efficacy of hydroxyapatite (HAp) as a carrier was investigated to establish a method of local administration of bisphosphonates (Bps), which has currently been administered systemically. HAp granules (300-500 microm in size) with different physicochemical features were prepared by altering the sintering temperature. To ascertain the physicochemical properties of the HAp granules, their crystallinity was assessed using X-ray diffraction, the surface morphology was examined under scanning electron microscopy, and the specific surface area and calcium dissolution were evaluated. Different Bps-HAp composites were subsequently prepared and the concentration of Bps released from these composites was measured. The influence of Bps-HAp composites on the rate of osteoclast survival was also evaluated. The results revealed that (1) HAp solubility depends on the sintering temperature; (2) The concentration of released Bps could be controlled by regulating the sintering temperature of HAp as a carrier; and (3) Bps released from Bps-HAp composites reduced the number of osteoclasts. These findings indicated that Bps-HAp composites could be locally administered as a drug delivery system to areas with bone resorption.

Details

Language :
English
ISSN :
1552-4973
Volume :
78
Issue :
2
Database :
MEDLINE
Journal :
Journal of biomedical materials research. Part B, Applied biomaterials
Publication Type :
Academic Journal
Accession number :
16544308
Full Text :
https://doi.org/10.1002/jbm.b.30446