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Control of bisphosphonate release using hydroxyapatite granules.
- Source :
-
Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2006 Aug; Vol. 78 (2), pp. 215-21. - Publication Year :
- 2006
-
Abstract
- The efficacy of hydroxyapatite (HAp) as a carrier was investigated to establish a method of local administration of bisphosphonates (Bps), which has currently been administered systemically. HAp granules (300-500 microm in size) with different physicochemical features were prepared by altering the sintering temperature. To ascertain the physicochemical properties of the HAp granules, their crystallinity was assessed using X-ray diffraction, the surface morphology was examined under scanning electron microscopy, and the specific surface area and calcium dissolution were evaluated. Different Bps-HAp composites were subsequently prepared and the concentration of Bps released from these composites was measured. The influence of Bps-HAp composites on the rate of osteoclast survival was also evaluated. The results revealed that (1) HAp solubility depends on the sintering temperature; (2) The concentration of released Bps could be controlled by regulating the sintering temperature of HAp as a carrier; and (3) Bps released from Bps-HAp composites reduced the number of osteoclasts. These findings indicated that Bps-HAp composites could be locally administered as a drug delivery system to areas with bone resorption.
- Subjects :
- Animals
Bone Resorption metabolism
Cell Survival drug effects
Cells, Cultured
Crystallization
Delayed-Action Preparations chemistry
Diphosphonates chemistry
Male
Materials Testing
Microscopy, Electron, Scanning
Rabbits
X-Ray Diffraction
Bone Resorption drug therapy
Diphosphonates pharmacology
Durapatite chemistry
Osteoclasts ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4973
- Volume :
- 78
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of biomedical materials research. Part B, Applied biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 16544308
- Full Text :
- https://doi.org/10.1002/jbm.b.30446