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Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin.
- Source :
-
Chinese journal of integrative medicine [Chin J Integr Med] 2006 Mar; Vol. 12 (1), pp. 19-23. - Publication Year :
- 2006
-
Abstract
- Objective: To evaluate the efficacy of Jiawei Huangqi Guizhi Wuwu Decoction (JHGWD) in treating neuro-sensory toxicity induced by oxaliplatin.<br />Methods: A randomized controlled self-crossover trial was performed. Thirty-one patients were randomly divided into AB and BA groups. Patients in A cycle belonged to the treated group, who were treated with chemotherapy combined with oxaliplatin plus JHGWD. Patients in B cycle belonged to the control group and were treated with chemotherapy alone. The peripheral neuro-sensory toxicity was observed and analyzed.<br />Results: The main neurotoxicity was cold-induced paresthesia after the use of oxaliplatin, which included hyperaesthesia, chill, anaesthesia in the extremities, electrified sensation, formication, foreign body sensation and pain that might be exacerbated by exposure to cold. Twenty patients (64.5%) suffered from neuro-sensory toxicity in the treated group and 27 cases (87.1%) in the control group. Symptoms were more serious and lasted longer in the control group than those in the treated group (P < 0.01).<br />Conclusion: JHGWD could prevent and reduce the occurrence and intensity of acute peripheral neuro-sensory toxicity caused by oxaliplatin.
- Subjects :
- Adult
Aged
Antineoplastic Agents therapeutic use
Cross-Over Studies
Female
Gastrointestinal Neoplasms drug therapy
Humans
Male
Middle Aged
Organoplatinum Compounds therapeutic use
Oxaliplatin
Paresthesia chemically induced
Paresthesia drug therapy
Paresthesia prevention & control
Peripheral Nervous System Diseases prevention & control
Antineoplastic Agents adverse effects
Drugs, Chinese Herbal therapeutic use
Organoplatinum Compounds adverse effects
Peripheral Nervous System Diseases chemically induced
Peripheral Nervous System Diseases drug therapy
Phytotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 1672-0415
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Chinese journal of integrative medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16571278
- Full Text :
- https://doi.org/10.1007/BF02857424