Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse.

Authors :: Kienzler F
Jedlicka P
Vuksic M
Deller T
Schwarzacher SW
Source :: Brain research [Brain Res] 2006 Apr 26; Vol. 1085 (1), pp. 195-8. Date of Electronic Publication: 2006 Apr 03.
Publication Year :: 2006
Abstract: Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefore, this mouse model of seizure-induced hippocampal injury can be used for a wide variety of studies in genetically altered conditions not available in rats.

Subjects :: Animals
Cell Count methods
Cell Death radiation effects
Disease Models, Animal
Epilepsy etiology
Epilepsy pathology
Epilepsy physiopathology
Functional Laterality
Mice
Mice, Inbred C57BL
Electric Stimulation
Hippocampus pathology
Neurons physiology
Perforant Pathway radiation effects

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