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Antiviral activity of the photoactive plant pigment hypericin.

Authors :
Lopez-Bazzocchi I
Hudson JB
Towers GH
Source :
Photochemistry and photobiology [Photochem Photobiol] 1991 Jul; Vol. 54 (1), pp. 95-8.
Publication Year :
1991

Abstract

The polycyclic compound hypericin, a known photodynamic agent, was investigated for antiviral activity in the presence and absence of light. The three viruses tested: murine cytomegalovirus; Sindbis virus; and human immunodeficiency virus type 1, were all susceptible to hypericin; but these antiviral activities were considerably enhanced, in a dose-dependent manner, by exposure to light.

Subjects

Subjects :
Animals
Anthracenes
Cell Line
Cytomegalovirus radiation effects
HIV-1 radiation effects
Humans
Light
Mice
Perylene pharmacology
Antiviral Agents pharmacology
Cytomegalovirus drug effects
HIV-1 drug effects
Perylene analogs & derivatives
Radiation-Sensitizing Agents pharmacology

Details

Language :
English
ISSN :
0031-8655
Volume :
54
Issue :
1
Database :
MEDLINE
Journal :
Photochemistry and photobiology
Publication Type :
Academic Journal
Accession number :
1658826
Full Text :
https://doi.org/10.1111/j.1751-1097.1991.tb01990.x
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