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Rising incidence and persistently high mortality of hospitalized pneumonia: a 10-year population-based study in Denmark.
- Source :
-
Journal of internal medicine [J Intern Med] 2006 Apr; Vol. 259 (4), pp. 410-7. - Publication Year :
- 2006
-
Abstract
- Background: Little is known about temporal trends in the incidence and mortality of pneumonia in the general population.<br />Methods: We conducted a population-based cohort study in three Danish counties (population 1.4 million) to examine changes in the incidence and 30- and 90-day mortality associated with hospitalized pneumonia between 1994 and 2004. All adults hospitalized with a first-time diagnosis of pneumonia (n = 41 793) were identified in hospital discharge registries and followed for mortality through the Danish Civil Registry System. We determined age-standardized incidence rates and adjusted mortality rates associated with calendar year, gender, age and comorbidity.<br />Results: Between 1994 and 2003, the incidence of hospitalized pneumonia amongst adults increased from 288 per 100 000 person-years to 442 per 100 000 person-years, equivalent to an age-standardized incidence rate ratio of 1.50. The cumulative mortality within 30 and 90 days of admission was 15.2% and 21.9%, respectively, ranging from a 90-day mortality of 2.5% in patients aged 15-39 years to 34.7% in those aged 80 and over. Advanced age was the most important poor prognostic factor, followed by a high comorbidity score and male gender. The adjusted mortality rate ratios amongst patients with hospitalized pneumonia in 1999-2004, when compared with 1994-1998, were 0.89 (95% CI 0.85-0.94) after 30 days and 0.91 (95% CI 0.88-0.95) after 90 days.<br />Conclusions: The incidence of hospitalized pneumonia in Denmark has increased considerably during the last 10 years and, combined with persistently high mortality rates, is of clinical and public health concern.
Details
- Language :
- English
- ISSN :
- 0954-6820
- Volume :
- 259
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16594909
- Full Text :
- https://doi.org/10.1111/j.1365-2796.2006.01629.x