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Dose dependent inhibitory effect of dietary caraway on 1,2-dimethylhydrazine induced colonic aberrant crypt foci and bacterial enzyme activity in rats.
- Source :
-
Investigational new drugs [Invest New Drugs] 2006 Nov; Vol. 24 (6), pp. 479-88. - Publication Year :
- 2006
-
Abstract
- Colon cancer has become one of the major causes of cancer mortality. We determined the effect of caraway (Carum carvi L.) on the development of aberrant crypt foci (ACF) and modulation of fecal bacterial enzyme activities in 1,2-dimethylhydrazine (DMH)-induced experimental rat colon carcinogenesis. Male Wistar albino rats were divided into six groups and all the animals were fed 15.8% peanut oil making a total of 20% fat in the diet. Group 1 served as control and group 2 animals received 90 mg/kg body weight caraway p.o. daily for 15 weeks. To induce ACF, DMH (20 mg/kg body weight) was injected subcutaneously once a week for the first four weeks (groups 3-6). In addition caraway was administered at the dose of 30, 60 and 90 mg/kg body weight everyday orally for the entire period of 15 weeks (groups 4-6). First, we analyzed ACF number (incidence), multiplicity and its distribution along the colon in all experimental groups at the end of 15 weeks. Subsequently, we also assayed the fecal bacterial enzyme activities. ACF formation and the fecal bacterial enzyme activities were found to be significantly high in DMH-alone treated group as compared to control group. Caraway supplementation at three different doses significantly suppressed ACF development, bacterial enzyme activities and modulated oxidative stress significantly as compared to the unsupplemented DMH-treated group. Results of our present study indicate that dietary caraway markedly inhibited DMH-induced colon carcinogenesis and the optimal dose of 60 mg/kg body weight was more effective than the other two doses.
- Subjects :
- 1,2-Dimethylhydrazine
Animals
Antineoplastic Agents, Phytogenic administration & dosage
Carcinogens
Catalase metabolism
Colon drug effects
Colonic Neoplasms chemically induced
Diet
Dose-Response Relationship, Drug
Feces enzymology
Feces microbiology
Lipid Peroxidation drug effects
Liver drug effects
Male
Plant Preparations administration & dosage
Precancerous Conditions chemically induced
Rats
Rats, Wistar
Superoxide Dismutase metabolism
Antineoplastic Agents, Phytogenic pharmacology
Bacteria enzymology
Carum
Colonic Neoplasms prevention & control
Plant Preparations pharmacology
Precancerous Conditions prevention & control
Seeds
Subjects
Details
- Language :
- English
- ISSN :
- 0167-6997
- Volume :
- 24
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Investigational new drugs
- Publication Type :
- Academic Journal
- Accession number :
- 16598436
- Full Text :
- https://doi.org/10.1007/s10637-006-6801-0