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Ablation of T-helper 1 cell derived cytokines and of monocyte-derived tumor necrosis factor-alpha in hereditary hemorrhagic telangiectasia: immunological consequences and clinical considerations.
Ablation of T-helper 1 cell derived cytokines and of monocyte-derived tumor necrosis factor-alpha in hereditary hemorrhagic telangiectasia: immunological consequences and clinical considerations.
- Source :
-
Current pharmaceutical design [Curr Pharm Des] 2006; Vol. 12 (10), pp. 1201-8. - Publication Year :
- 2006
-
Abstract
- Experimental evidences on the adaptive immune response in patients with hereditary hemorragic telagiectasia (HHT) are lacking. Here, we report in 9 patients with HHT a multiple deficit involving the intracellular expression of T helper (h)1-derived cytokines [Interferon (IFN)-gamma, Interleukin (IL)-2 and Tumor Necrosis Factor (TNF)-alpha] and of monocyte-derived TNF-alpha. On the other hand, percentages of Th2-derived cytokines (IL-4, IL-5 and IL-10) were normal or, in some cases, above normality. Quite interestingly, monocyte-derived IL-10 was detectable in 5 out of 9 patients in a percentage of cells comparable to controls or exceeding normal levels. Taken together, these data point out, in HHT, an ablation of Th1-responses, while Th2-type cytokines are preserved, thus exerting either a suppressive effect on Th1-cells (via IL-4 and IL-10) or an antiinflammatory response on monocyte-derived TNF-alpha (via IL-10). Furthermore, monocyte-derived IL-10 may also contribute to the antiinflammatory activity seen in HHT. According to current literature even if patients with HHT do not exhibit certain diseases, such as autoimmune diseases, cancer and abnormal responses to pathogens, the observed immune deficits need to be diagnosed and therapeutically corrected.
- Subjects :
- Adult
Aged
Cytokines immunology
Female
Flow Cytometry
Humans
Interleukin-10 metabolism
Male
Middle Aged
Monocytes immunology
Phenotype
T-Lymphocytes, Helper-Inducer immunology
Tetradecanoylphorbol Acetate pharmacology
Th1 Cells immunology
Th2 Cells immunology
Tumor Necrosis Factor-alpha immunology
Cytokines metabolism
Monocytes metabolism
T-Lymphocytes, Helper-Inducer metabolism
Telangiectasia, Hereditary Hemorrhagic immunology
Tumor Necrosis Factor-alpha metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1381-6128
- Volume :
- 12
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Current pharmaceutical design
- Publication Type :
- Academic Journal
- Accession number :
- 16611101
- Full Text :
- https://doi.org/10.2174/138161206776361372