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[PLAC1/CP1 gene expression and autologous humoral immunity in gastric cancer patients].
- Source :
-
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2006 Apr 18; Vol. 38 (2), pp. 124-7. - Publication Year :
- 2006
-
Abstract
- Objective: To investigate PLAC1/CP1 as a potential candidate gene in gastric cancer therapy.<br />Methods: Reverse transcription-polymerase chain reaction (RT-PCR) method was used to detect the expression of PLAC1/CP1 mRNA in gastric cancer tissues and paired adjacent non-cancerous tissues resected from 28 patients with gastric cancer. Specific antibodies against PLAC1/CP1 were also detected by ELISA method in gastric cancer patients.<br />Results: Fourteen (50%,14/28) out of the 28 gastric cancer samples were PLAC1/CP1 mRNA positive. Of the 28 serum samples tested,eight (29%,8/28) displayed positive seroreactivity against PLAC1/CP1 antigen, accounting for 57% (8/14) of PLAC1/CP1 mRNA positive samples.<br />Conclusion: PLAC1/CP1 mRNA was expressed in high frequency and induced spontaneous antibody responses in gastric cancer patients. PLAC1/CP1 may be a valuable candidate antigen in gastric cancer immunotherapy.
Details
- Language :
- Chinese
- ISSN :
- 1671-167X
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16617350