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Gamma-aminobutyric acidA (GABAA) receptor modulation of morphine inhibition of norepinephrine release.
- Source :
-
Biochemical pharmacology [Biochem Pharmacol] 1991 Dec 11; Vol. 42 Suppl, pp. S121-6. - Publication Year :
- 1991
-
Abstract
- Agents that enhance gamma-aminobutyric acid (GABA) neurotransmission can modulate certain effects of opioids, such as analgesia. In this study, the interaction between morphine and GABAergic agents on the release of [3H]norepinephrine ([3H]NE) from rat frontal cortical slices was examined. GABA (10(-4) M), enhanced potassium-stimulated [3H]NE release and reversed the inhibitory effect of 10(-6) M morphine. GABA and muscimol modulated the inhibitory effect of morphine in a noncompetitive manner. Bicuculline methiodide (10(-4) M) reduced the effect of GABA in the absence of morphine, and appeared to reduce the effect of GABA in the presence of morphine, although the latter effect was not statistically significant from the controls. While the GABAA agonist muscimol mimicked the effect of GABA, the GABAB agonist baclofen did not affect the release of [3H]NE in the absence or the presence of 10(-6) M morphine. These results support the involvement of GABAA receptors in modulating the action of opioids on the noradrenergic system in the cerebral cortex of the rat.
- Subjects :
- Animals
Baclofen pharmacology
Cerebral Cortex drug effects
Dose-Response Relationship, Drug
In Vitro Techniques
Male
Norepinephrine antagonists & inhibitors
Rats
Rats, Inbred Strains
Morphine pharmacology
Norepinephrine metabolism
Receptors, GABA-A drug effects
gamma-Aminobutyric Acid pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-2952
- Volume :
- 42 Suppl
- Database :
- MEDLINE
- Journal :
- Biochemical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1662949
- Full Text :
- https://doi.org/10.1016/0006-2952(91)90401-p