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[Effects of enhanced external counterpulsation in atherosclerosis and NF-kappaB expression: a pig model with hypercholesterolemia].
- Source :
-
Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2006 Mar; Vol. 35 (3), pp. 159-64. - Publication Year :
- 2006
-
Abstract
- Objective: To study the effects of enhanced external counterpulsation (EECP) on the vascular morphology, and endothelial function using experimentally induced hypercholesterolemic pigs.<br />Methods: Thirty five male pigs were randomly divided into three groups: 7 normal control animals, 11 hypercholesterolemic animals, and 17 hypercholesterolemic animals receiving EECP. Serum cholesterol was measured. The coronary arteries and aortas were sampled for histopathologic and ultrastructural examination. The NF-kappaB protein expression of porcine coronary arteries was investigated by immunofluorescence.<br />Results: Compared with the normal controls, serum cholesterol levels were significantly higher in the hypercholesterolemic animals with or without EECP. The plaque/intimal area ratio of the aorta decreased significantly in animals receiving EECP [(3.33 +/- 2.40)%, versus (12.03 +/- 7.12)% in those without EECP, P < 0.05]. Lipid deposition, endothelial damage and proliferation of smooth muscle cells were less severe in animals receiving EECP than those not. Moreover, activation and expression of NF-kappaB also decreased significantly (P < 0.05) in animals receiving EECP.<br />Conclusions: EECP improves the morphology and function of vascular endothelium, and retards the development and progression of atherosclerosis, likely through the inhibition of NF-kappaB signaling pathway.
- Subjects :
- Animals
Aorta, Abdominal metabolism
Aorta, Abdominal pathology
Aorta, Abdominal ultrastructure
Atherosclerosis blood
Atherosclerosis metabolism
Cholesterol blood
Coronary Vessels metabolism
Coronary Vessels pathology
Coronary Vessels ultrastructure
Endothelial Cells metabolism
Endothelial Cells pathology
Hypercholesterolemia blood
Hypercholesterolemia metabolism
Lipoproteins, LDL blood
Male
Microscopy, Confocal
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Muscle, Smooth, Vascular metabolism
Muscle, Smooth, Vascular pathology
Random Allocation
Swine
Atherosclerosis pathology
Counterpulsation methods
Hypercholesterolemia pathology
NF-kappa B metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0529-5807
- Volume :
- 35
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua bing li xue za zhi = Chinese journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 16630505