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The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Jul 01; Vol. 16 (13), pp. 3489-94. Date of Electronic Publication: 2006 May 02. - Publication Year :
- 2006
-
Abstract
- Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERbeta subtype selective ligands are described. Several analogs possessing ERbeta binding affinities comparable to 17beta-estradiol but with greater than 75-fold selectivity over ERalpha are reported.
- Subjects :
- Cell Line
Crystallography, X-Ray
Estrogen Receptor alpha chemistry
Estrogen Receptor alpha drug effects
Estrogen Receptor beta chemistry
Fluorenes classification
Humans
Ligands
Models, Molecular
Molecular Structure
Stereoisomerism
Structure-Activity Relationship
Estrogen Receptor beta drug effects
Fluorenes chemical synthesis
Fluorenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16632357
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.03.098