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[Expressions of oncogene products in adenoid cystic carcinomas of salivary glands: immunohistochemical study].
- Source :
-
Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan [Kokubyo Gakkai Zasshi] 1991 Dec; Vol. 58 (4), pp. 696-717. - Publication Year :
- 1991
-
Abstract
- In 43 cases of adenoid cystic carcinomas of the salivary glands (ACC), expressions of the oncogene products such as epidermal growth factor receptor (EGF-R), erbB-2 product, c-myc product and N-myc product were investigated immunohistochemically. First, we confirmed the specificity of the antibodies used with the 13 cell lines. Of the anti-EGF-R antibodies, clone 29. 1. 1 reacted only with A431 but not with the other cell lines overexpressing EGF-R, so that it was most likely to cross-react with the blood type A antigen. Also, the anti-N-myc product antibody revealed the presence of a certain cross-reacting antigen in Lu65. Overexpression of EGF-R was observed in only one case. Nine cases (20.9%) showing tubular and cribriform patterns overexpressed the erbB-2 product, but the signals were mainly localized in the cytoplasm as a granular appearance. Eighteen cases (41.9%) with slight cellular atypia showed an overexpression of the c-myc product. The immunolocalization of the c-myc product was at the nuclei in most cases, or both the nuclei and the cytoplasm in some cases. None of the ACC expressed the N-myc product. It is speculated that the multiple oncogene expressions might be partly related to the acquirement of the differentiated or malignant phenotype in the ACC.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Adenoid Cystic genetics
Carcinoma, Adenoid Cystic pathology
Female
Humans
Immunohistochemistry
Male
Middle Aged
Salivary Gland Neoplasms genetics
Salivary Gland Neoplasms pathology
Carcinoma, Adenoid Cystic metabolism
Oncogene Proteins analysis
Oncogenes
Salivary Gland Neoplasms metabolism
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0300-9149
- Volume :
- 58
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan
- Publication Type :
- Academic Journal
- Accession number :
- 1665502
- Full Text :
- https://doi.org/10.5357/koubyou.58.696