Back to Search
Start Over
Development of a whole killed feline leukemia virus vaccine.
- Source :
-
Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 1991 Nov 15; Vol. 199 (10), pp. 1419-22. - Publication Year :
- 1991
-
Abstract
- A whole killed FeLV vaccine was developed. By use of a chromatography method of purification and concentration, the resulting vaccine has been shown to be significantly lower in bovine serum albumin and total protein contents than were the same ingredients in the starting materials. The virus was inactivated or killed as an essential part of the vaccine development process. Vaccination trials with the vaccine without use of adjuvants indicated appreciable virus-neutralizing serum titer (greater than or equal to 1:10) in 107 of 110 vaccinated cats. Of 43 cats vaccinated and subsequently challenge exposed with virulent FeLV, only 2 developed persistent virus antigenemia (longer than 1 month), whereas 14 of 22 nonvaccinated control cats developed persistent viremia. In field tests, 2,770 cats from 6 states were vaccinated and observed. Postvaccinal reactions were not observed.
- Subjects :
- Animals
Antibodies, Viral blood
Antigens, Viral blood
Cats
Chromatography
Neutralization Tests
Retroviridae Proteins, Oncogenic immunology
Retroviridae Proteins, Oncogenic standards
Vaccines, Inactivated analysis
Vaccines, Inactivated immunology
Vaccines, Inactivated standards
Viral Vaccines immunology
Viral Vaccines standards
Viremia prevention & control
Viremia veterinary
Leukemia Virus, Feline immunology
Leukemia, Feline prevention & control
Retroviridae Proteins, Oncogenic analysis
Vaccination veterinary
Viral Vaccines analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0003-1488
- Volume :
- 199
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of the American Veterinary Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 1666095