Back to Search
Start Over
First-principles transversal DNA conductance deconstructed.
- Source :
-
Biophysical journal [Biophys J] 2006 Jul 01; Vol. 91 (1), pp. L04-6. Date of Electronic Publication: 2006 May 05. - Publication Year :
- 2006
-
Abstract
- First-principles calculation of the transverse conductance across DNA fragments placed between gold nanoelectrodes reveals that such conductance describes electron tunneling that depends critically on geometrical rather than electronic-structure properties. By factoring the first-principles result into two simple and approximately independent tunneling factors, we show that the conductances of the A, C, G, and T fragments differ only because of their sizes: the larger is the DNA base, the smaller its distance to the electrode, and the larger its conductance. Because the geometrical factors are difficult to control in an experiment, the direct-current measurements across DNA with gold contact electrodes may not be a convenient approach to DNA sequencing.
Details
- Language :
- English
- ISSN :
- 0006-3495
- Volume :
- 91
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biophysical journal
- Publication Type :
- Academic Journal
- Accession number :
- 16679371
- Full Text :
- https://doi.org/10.1529/biophysj.106.085548