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Determination of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound, by high performance liquid chromatography with ultraviolet spectrometry.
- Source :
-
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2006 Jun 06; Vol. 837 (1-2), pp. 108-11. Date of Electronic Publication: 2006 May 09. - Publication Year :
- 2006
-
Abstract
- 1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity. In the present study, pharmacokinetic parameters for FPP-3 and its metabolites were determined at the same time by using high-performance liquid chromatography-ultraviolet spectrometry. Two metabolites were detected in sera when FPP-3 was administered intravenously to male SD rats. The linearity of FPP-3, M1 (1-furan-2-yl-3-pyridin-2-yl-propan-1-one) and M2 (1-furan-2-yl-3-pyridin-2-yl-propan-1-ol) was confirmed in the concentration ranges of 0.5-20, 0.101-4.04 and 1.04-20.4 microg/ml, respectively. The lower limits of quantitation of FPP-3, M1 and M2 were 0.5, 0.1 and 1.0 microg/ml, respectively. The intra- and inter-day precision and accuracy over the concentration range of target compounds were within 13.5 and 14.2%, respectively. The half-lives of FPP-3, M1 and M2 were 16.3, 27.7 and 22.1 min, respectively.
- Subjects :
- Animals
Anti-Inflammatory Agents pharmacokinetics
Furans pharmacokinetics
Male
Propane blood
Propane pharmacokinetics
Pyridines pharmacokinetics
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Sensitivity and Specificity
Anti-Inflammatory Agents blood
Chromatography, High Pressure Liquid methods
Furans blood
Propane analogs & derivatives
Pyridines blood
Spectrophotometry, Ultraviolet methods
Subjects
Details
- Language :
- English
- ISSN :
- 1570-0232
- Volume :
- 837
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 16687255
- Full Text :
- https://doi.org/10.1016/j.jchromb.2006.04.010