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Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years' endoscopical survey.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2006 Apr 21; Vol. 12 (15), pp. 2398-401. - Publication Year :
- 2006
-
Abstract
- Aim: To compare peptic ulcer prevalence in patients referred for upper gastrointestinal endoscopy in two Italian hospitals in pre-Helicobacter era and ten years after the progressive diffusion of eradication therapy.<br />Methods: We checked all the endoscopic examinations consecutively performed in the Gastroenterology Unit of Padova during 1986-1987 and 1995-1996, and in the Gastroenterology Unit of Parma during 1992 and 2002. Chi Square test was used for statistic analysis.<br />Results: Data from both the endoscopic centers showed a statistically significant decrease in the prevalence of ulcers: from 12.7% to 6.3% (P<0.001) in Padova and from 15.6% to 12% (P<0.001) in Parma. The decrease was significant both for duodenal (from 8.8% to 4.8%, P<0.001) and gastric ulcer (3.9% to 1.5%, P<0.001) in Padova, and only for duodenal ulcer in Parma (9.2% to 6.1%, P<0.001; gastric ulcer: 6.3% to 5.8%, NS).<br />Conclusion: Ten years of extensive Helicobacter pylori (H pylori) eradication in symptomatic patients led to a significant reduction in peptic ulcer prevalence. This reduction was particularly evident in Padova, where a project for the sensibilization of H pylori eradication among general practioners was carried out between 1990 and 1992. Should our hypothesis be true, H pylori eradication might in the future lead to peptic ulcer as a rare endoscopic finding.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Endoscopy, Gastrointestinal
Female
Humans
Italy epidemiology
Male
Middle Aged
Peptic Ulcer epidemiology
Peptic Ulcer etiology
Retrospective Studies
Time Factors
Helicobacter Infections complications
Helicobacter Infections drug therapy
Helicobacter pylori
Peptic Ulcer prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1007-9327
- Volume :
- 12
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 16688832
- Full Text :
- https://doi.org/10.3748/wjg.v12.i15.2398