Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.

Authors :: Takeyama K
Yoshikawa M
Oka T
Kawaguchi M
Suzuki T
Hashimoto A
Source :: European journal of pharmacology [Eur J Pharmacol] 2006 Jul 01; Vol. 540 (1-3), pp. 82-6. Date of Electronic Publication: 2006 Apr 28.
Publication Year :: 2006
Abstract: We have evaluated the effects of the acute administration of noncompetitive N-methyl-D-aspartate receptor antagonist, ketamine, on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors.

Subjects :: Anesthetics, Dissociative pharmacology
Animals
Brain enzymology
Brain metabolism
Cerebellum drug effects
Cerebellum enzymology
Cerebellum metabolism
Cerebral Cortex drug effects
Cerebral Cortex enzymology
Cerebral Cortex metabolism
Corpus Striatum drug effects
Corpus Striatum enzymology
Corpus Striatum metabolism
Diencephalon drug effects
Diencephalon enzymology
Diencephalon metabolism
Dose-Response Relationship, Drug
Hippocampus drug effects
Hippocampus enzymology
Hippocampus metabolism
Male
Mesencephalon drug effects
Mesencephalon enzymology
Mesencephalon metabolism
Pons drug effects
Pons enzymology
Pons metabolism
RNA, Messenger genetics
Rats
Rats, Wistar
Brain drug effects
D-Amino-Acid Oxidase genetics
Gene Expression Regulation, Enzymologic drug effects
Ketamine pharmacology
RNA, Messenger metabolism
Racemases and Epimerases genetics

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