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[Neurofibromatosis type 1 complications in the pediatric age: follow-up of a hundred cases].
- Source :
-
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie [Arch Pediatr] 2006 Jul; Vol. 13 (7), pp. 1009-14. Date of Electronic Publication: 2006 May 22. - Publication Year :
- 2006
-
Abstract
- Unlabelled: Neurofibromatosis 1 (NF1) is a frequent genetic disease. Diagnostic criterias were established in 1988. The patients can exhibit various and unpredictable complications.<br />Objectives: To check the efficiency of a coordinated follow-up in specialized multidisciplinary centers providing a higher quality of management and to have a better knowledge of the complications including their true frequencies.<br />Population and Methods: We report a serie of 100 NF1 children who were followed-up during 4 years in a specialized center at the Tours University Hospital. Three hospital check-up at 2-5, 6-7, 14-15 years of age were performed as well as an annual physical examination.<br />Results: In our serie, the mean age was 7.8 years old with a sex ratio of 1. The mean age at diagnosis was 3.8 years old and the main diagnosis criteria were the café-au-lait spots and the family history for 80% of the patients. The optic nerve glioma has a low frequency of 5%. Learning disabilities clearly represent the most frequent complication (46% of the patients).<br />Conclusion: An early detection of these difficulties is a priority for the appropriate management of these children.
Details
- Language :
- French
- ISSN :
- 0929-693X
- Volume :
- 13
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
- Publication Type :
- Academic Journal
- Accession number :
- 16716577
- Full Text :
- https://doi.org/10.1016/j.arcped.2006.03.149