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Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Aug 01; Vol. 16 (15), pp. 3891-5. Date of Electronic Publication: 2006 Jun 02. - Publication Year :
- 2006
-
Abstract
- The synthesis of 24-membered macrocycles containing four, six, and seven oxazole moieties is described. Selected compounds were evaluated for their ability to specifically bind and stabilize G-quadruplex DNA and for cytotoxic activity. An unexpected oxidative cleavage reaction afforded a macrocyclic imide that was also evaluated for G-quadruplex stabilizing and cytotoxic activity.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16735121
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.05.038