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Osteoporosis and bone metabolism in postmenopausal women with osteoarthritis of the hand.

Authors :
Zoli A
Lizzio MM
Capuano A
Massafra U
Barini A
Ferraccioli G
Source :
Menopause (New York, N.Y.) [Menopause] 2006 May-Jun; Vol. 13 (3), pp. 462-6.
Publication Year :
2006

Abstract

Objective: Osteoarthritis and osteoporosis are two major health problems affecting postmenopausal women. Epidemiological observations seem to demonstrate a possible inverse relationship between osteoarthritis and osteoporosis. Erosive osteoarthritis (EOA) of the hand is a destructive form of primary osteoarthritis. This study evaluated bone mineral density and bone metabolism changes in erosive and nonerosive hand osteoarthritis women.<br />Design: Fifty-five women (mean age, 59 years; body mass index, 23 +/- 1.4 kg/m) who had been postmenopausal for an average of 9 years and who presented with hand osteoarthritis according to American College of Rheumatology criteria were enrolled in the study; 15 women showed clinical and radiological evidence of hand EOA. Twenty women matched for age, age at menopause, and body mass index formed the control group. Bone mineral density (g/cm) was measured at the hip and lumbar spine using dual-energy x-ray absorptiometry. Serum and urinary calcium and phosphate, serum 25-hydroxyvitamin D, parathyroid hormone, osteocalcin, and urinary breakdown products of bone matrix (CrossLaps) were analyzed.<br />Results: Women with hand EOA had a statistically significant lower T- and Z-score L2-L4 value than non-hand EOA women and controls (P < 0.01). Moreover, postmenopausal women with hand EOA had higher significant percentage of osteoporosis at lumbar spine when compared with non-hand EOA postmenopausal women and controls. Any statistically significant difference in osteocalcin and CrossLaps serum levels was noted among women with hand EOA, hand osteoarthritis, and controls.<br />Conclusions: Our data suggest that postmenopausal women with clinical and radiological EOA are at risk for development of osteoporosis.

Details

Language :
English
ISSN :
1072-3714
Volume :
13
Issue :
3
Database :
MEDLINE
Journal :
Menopause (New York, N.Y.)
Publication Type :
Academic Journal
Accession number :
16735943
Full Text :
https://doi.org/10.1097/01.gme.0000179048.08371.8e