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Gemcitabine in combination with vinorelbine for heavily pretreated advanced breast cancer.
- Source :
-
Anticancer research [Anticancer Res] 2006 Jan-Feb; Vol. 26 (1B), pp. 549-52. - Publication Year :
- 2006
-
Abstract
- Purpose: To evaluate the activity and toxicity of gemcitabine and vinorelbine in patients with metastatic breast cancer (MBC), previously treated with anthracyclines alone or with taxanes.<br />Patients and Methods: A total of 86 pretreated patients with MBC (median age 62 years), entered the study. Thirty-six patients had been pretreated with anthracyclines and 8 were resistant. The combination of gemcitabine (1000 mg/m2) and vinorelbine (25 mg/m2) was administered on days 1 and 8 every 3 weeks, for a total of 6 cycles.<br />Results: A total of 344 cycles of chemotherapy were administered (median 4 cycles per patient). Partial responses were observed in 31 patients (36.0%; 95% CI: 23-56). The median duration of response was 7 months (range 3-11 months) and the median overall survival was 14 months (range 6-21). The scheme was well tolerated.<br />Conclusion: The combination of vinorelbine and gemcitabine is an active scheme in pretreated MBC, demonstrating an acceptable toxicity profile, and may well represent a valuable therapeutic choice after anthracycline/taxane regimens.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols adverse effects
Breast Neoplasms pathology
Deoxycytidine administration & dosage
Deoxycytidine adverse effects
Deoxycytidine analogs & derivatives
Drug Administration Schedule
Female
Humans
Middle Aged
Vinblastine administration & dosage
Vinblastine adverse effects
Vinblastine analogs & derivatives
Vinorelbine
Gemcitabine
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Breast Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 26
- Issue :
- 1B
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 16739318