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Peroxisome proliferator-activated receptor-gamma polymorphism, body mass and prostate cancer risk: evidence for gene-environment interaction.
- Source :
-
Oncology [Oncology] 2006; Vol. 70 (3), pp. 185-9. Date of Electronic Publication: 2006 Jun 07. - Publication Year :
- 2006
-
Abstract
- Background: Peroxisome proliferator-activated receptor (PPAR)-gamma has been implicated in prostate cancer. In the present case-control study, we tested if a common Pro12Ala polymorphism in PPAR-gamma is associated with the risk of prostate cancer.<br />Methods: Ninety-one adult Caucasians with prostate cancer were recruited between 1994 and 1998. Blood samples were also obtained from 237 community-based Caucasian men without prostate cancer.<br />Results: Twenty-six percent of cases and 19% of controls carried at least one Ala allele (p = 0.16). There was a significant interaction between the PPAR-gamma polymorphism and body mass index (BMI) in age-adjusted analyses (p < 0.05). Among the subgroup of men with BMI above 27.2 kg/m2 (median in controls), carriers of the Ala allele had over 2-fold greater risk of prostate cancer compared to those with the Pro12Pro genotype (odds ratio, OR: 2.77; 95% confidence interval, CI: 1.25-6.16). No association was observed between the PPAR-gamma genotype and prostate cancer among men with BMI below the median (OR: 0.68; 95% CI: 0.23-1.97).<br />Conclusions: Our results suggest a novel gene-environment interaction between the PPAR-gamma Pro12Ala polymorphism and body mass in prostate cancer. Further research, particularly prospective studies, is needed to confirm these findings and to clarify the underlying mechanisms involved.<br /> (Copyright 2006 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Alanine
Case-Control Studies
Genotype
Humans
Insulin blood
Male
Middle Aged
Odds Ratio
Predictive Value of Tests
Proline
Prostatic Neoplasms blood
Prostatic Neoplasms epidemiology
Prostatic Neoplasms genetics
Waist-Hip Ratio
Body Mass Index
PPAR gamma genetics
Polymorphism, Genetic
Prostatic Neoplasms etiology
Prostatic Neoplasms physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0030-2414
- Volume :
- 70
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 16763406
- Full Text :
- https://doi.org/10.1159/000093805