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[Age-related changes serum levels of MMP-1 and MMP-2 in women: their relationship with bone biochemical markers and bone mineral density].
- Source :
-
Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2006 Apr; Vol. 45 (4), pp. 306-9. - Publication Year :
- 2006
-
Abstract
- Objective: To study the relationship between serum matrix metalloproteinase (MMP)-1, MMP-2 and bone turnover markers, bone mineral density (BMD) in Chinese women aged 20-80 years.<br />Methods: Serum MMP-1, MMP-2, bone alkaline phosphatase (BAP), osteocalcin (OC) and cross-linked N-telopeptide of collagen type I (NTX) were measured using ELISA. BMD were measured using DEXA in 591 women.<br />Results: (1) MMP-1 and MMP-2 were positively correlated with age (both P < 0.001). (2) Level of MMP-2 in postmenopausal women was significantly higher than that in premenopausal women (P < 0.001). (3) Significant negative relationship was found between MMP-2 and BMD, but multiple linear stepwise regression analysis showed MMP-2 was not the determinant factor of BMD. (4) Positive correlation was found between MMP-2 and BAP, OC, NTX (all P < 0.001). (5) Serum MMP-2 concentrations were significantly higher in postmenopausal osteoporotic women than in age-matched normal controls and osteopenic subjects.<br />Conclusion: Circulating MMP-2 and markers of bone turnover are related and they may increase with the increase in bone-turnover. The increase of serum MMP-2 appears possibly as a concomitant event in high bone turnover state such as postmenopausal osteoporosis.
- Subjects :
- Adult
Age Factors
Aged
Aged, 80 and over
Biomarkers blood
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Middle Aged
Osteocalcin blood
Osteoporosis, Postmenopausal physiopathology
Bone Density physiology
Matrix Metalloproteinase 1 blood
Matrix Metalloproteinase 2 blood
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0578-1426
- Volume :
- 45
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhonghua nei ke za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 16780680