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Corticosteroids can reverse severe imatinib-induced hepatotoxicity.
- Source :
-
Haematologica [Haematologica] 2006 Jun; Vol. 91 (6 Suppl), pp. ECR27. - Publication Year :
- 2006
-
Abstract
- Background: Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation.<br />Design and Results: We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence.<br />Conclusions: Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.
- Subjects :
- Benzamides
Humans
Imatinib Mesylate
Liver drug effects
Methylprednisolone therapeutic use
Prednisone therapeutic use
Adrenal Cortex Hormones therapeutic use
Antineoplastic Agents adverse effects
Chemical and Drug Induced Liver Injury
Leukemia, Myelogenous, Chronic, BCR-ABL Positive drug therapy
Liver pathology
Liver Diseases drug therapy
Piperazines adverse effects
Pyrimidines adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1592-8721
- Volume :
- 91
- Issue :
- 6 Suppl
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 16785130