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Expanding the scales: The multiple roles of MCH in regulating energy balance and other biological functions.
- Source :
-
Endocrine reviews [Endocr Rev] 2006 Oct; Vol. 27 (6), pp. 606-20. Date of Electronic Publication: 2006 Jun 20. - Publication Year :
- 2006
-
Abstract
- Melanin-concentrating hormone (MCH) is a cyclic peptide originally identified as a 17-amino-acid circulating hormone in teleost fish, where it is secreted by the pituitary in response to stress and environmental stimuli. In fish, MCH lightens skin color by stimulating aggregation of melanosomes, pigment-containing granules in melanophores, cells of neuroectodermal origin found in fish scales. Although the peptide structure between fish and mammals is highly conserved, in mammals, MCH has no demonstrable effects on pigmentation; instead, based on a series of pharmacological and genetic experiments, MCH has emerged as a critical hypothalamic regulator of energy homeostasis, having effects on both feeding behavior and energy expenditure.
- Subjects :
- Amino Acid Sequence
Animals
Homeostasis physiology
Humans
Hypothalamic Hormones chemistry
Melanins chemistry
Molecular Sequence Data
Pituitary Hormones chemistry
Energy Metabolism physiology
Feeding Behavior physiology
Hypothalamic Hormones physiology
Melanins physiology
Pituitary Hormones physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0163-769X
- Volume :
- 27
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Endocrine reviews
- Publication Type :
- Academic Journal
- Accession number :
- 16788162
- Full Text :
- https://doi.org/10.1210/er.2006-0021