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Novel peroxidase mimics: mu-Aqua manganese-Schiff base dimers.
- Source :
-
Journal of inorganic biochemistry [J Inorg Biochem] 2006 Sep; Vol. 100 (9), pp. 1470-8. Date of Electronic Publication: 2006 May 10. - Publication Year :
- 2006
-
Abstract
- The interaction of manganese(II) carboxylate salts [Mn(O(2)CR)(2), where R=ethane, pentane] with H(2)L(1) [N,N'-bis(3-methoxy-2-hydroxybenzaldehyde)-1,2-phenylenediamine] and H(2)L(2) [N,N'-bis(3-ethoxy-2-hydroxybenzaldehyde)-1,2-phenylenediamine] was studied. MnL(1)(O(2)CEt)(H(2)O) (1), MnL(1)(O(2)CPe(n))(H(2)O) (2), MnL(2)(O(2)CEt)(H(2)O)(2) (3) and MnL(2)(O(2)CPe(n))(H(2)O)(2) (4) were isolated and thoroughly characterised by elemental analysis, FAB mass spectrometry, infrared and (1)H NMR spectroscopy, magnetic susceptibility measurements, molar conductivities, and cyclic and normal pulse voltammetry. Compounds 1 and 2 were crystallographically characterised revealing a tetragonally elongated octahedral geometry for the manganese coordination sphere and also a dimeric nature through mu-aqua bridges. Complexes 1-4 behave as efficient peroxidase mimics in the presence of the water-soluble trap ABTS, probably due to their ease to coordinate the substrate molecule. A correlation between rhombicity of the complexes and peroxidase activity has also been established.
- Subjects :
- Carboxylic Acids chemistry
Crystallography, X-Ray
Dimerization
Electrochemistry
Magnetic Resonance Spectroscopy
Molecular Conformation
Molecular Structure
Phenylenediamines chemistry
Manganese Compounds chemical synthesis
Manganese Compounds chemistry
Peroxidase chemistry
Schiff Bases chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0162-0134
- Volume :
- 100
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of inorganic biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 16790277
- Full Text :
- https://doi.org/10.1016/j.jinorgbio.2006.04.012