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ERP/CSD indices of impaired verbal working memory subprocesses in schizophrenia.

Authors :
Kayser J
Tenke CE
Gates NA
Kroppmann CJ
Gil RB
Bruder GE
Source :
Psychophysiology [Psychophysiology] 2006 May; Vol. 43 (3), pp. 237-52.
Publication Year :
2006

Abstract

To disentangle subprocesses of verbal working memory deficits in schizophrenia, long EEG epochs (>10 s) were recorded from 13 patients and 17 healthy adults during a visual word serial position test. ERP generator patterns were summarized by temporal PCA from reference-free current source density (CSD) waveforms to sharpen 31-channel topographies. Patients showed poorer performance and reduced left inferior parietotemporal P3 source. Build-up of mid-frontal negative slow wave (SW) in controls during item encoding, integration, and active maintenance was absent in patients, whereas a sustained mid-frontal SW sink during the retention interval was comparable across groups. Mid-frontal SW sinks (encoding and retention periods) and posterior SW sinks and sources (encoding only) were related to performance in controls only. Data suggest disturbed processes in a frontal-parietotemporal network in schizophrenia, affecting encoding and early item storage.

Details

Language :
English
ISSN :
0048-5772
Volume :
43
Issue :
3
Database :
MEDLINE
Journal :
Psychophysiology
Publication Type :
Academic Journal
Accession number :
16805862
Full Text :
https://doi.org/10.1111/j.1469-8986.2006.00398.x