The role of hippocampal sclerosis in antiepileptic drug-related depression in patients with epilepsy: a study on levetiracetam.

Authors :: Mula M
Sander JW
Trimble MR
Source :: Seizure [Seizure] 2006 Sep; Vol. 15 (6), pp. 405-8. Date of Electronic Publication: 2006 Jun 30.
Publication Year :: 2006
Abstract: Objective: Hippocampal sclerosis (HS) has been described as a relevant factor for the development of topiramate-related depression and cognitive deficits. The aim of our study was to clarify whether patients with temporal lobe epilepsy (TLE) and HS were also at risk during therapy with levetiracetam (LEV).<br />Methods: Data of 156 patients was analysed: 78 with TLE and HS and 78 with TLE and normal MRI matched for age, starting dose and titration schedule of LEV. Patients were selected from a population of consecutive patients started on LEV between 2000 and 2002.<br />Results: No differences were observed in prevalence of cognitive adverse events and depression between the two groups.<br />Conclusions: LEV treatment is not associated with cognitive adverse events and depression in patients with hippocampal sclerosis.

Subjects :: Adult
Anticonvulsants therapeutic use
Epilepsy, Temporal Lobe drug therapy
Female
Humans
Levetiracetam
Male
Piracetam adverse effects
Piracetam therapeutic use
Sclerosis
Anticonvulsants adverse effects
Cognition Disorders chemically induced
Depression chemically induced
Epilepsy, Temporal Lobe psychology
Hippocampus pathology
Piracetam analogs & derivatives

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