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Decreased levels of insulin-like growth factor-1 and vascular endothelial growth factor relevant to the ossification disturbance in femoral heads spontaneous hypertensive rats.
- Source :
-
Acta medica Okayama [Acta Med Okayama] 2006 Jun; Vol. 60 (3), pp. 141-8. - Publication Year :
- 2006
-
Abstract
- Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p<0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR.
- Subjects :
- Animals
Chondrocytes chemistry
Chondrocytes pathology
Growth Plate chemistry
Growth Plate pathology
Immunohistochemistry
Ossification, Heterotopic blood
Ossification, Heterotopic etiology
Ossification, Heterotopic pathology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Epidermal Growth Factor metabolism
Femur Head Necrosis blood
Femur Head Necrosis physiopathology
Hypertension physiopathology
Insulin-Like Growth Factor I metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0386-300X
- Volume :
- 60
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Acta medica Okayama
- Publication Type :
- Academic Journal
- Accession number :
- 16838042
- Full Text :
- https://doi.org/10.18926/AMO/30749